ATF2 and RUVBL2

Number of citations of the paper that reports this interaction (PubMedID 11713276)
24

Data Source:
HPRD (two hybrid, in vivo)

		ATF2	RUVBL2
Description		activating transcription factor 2	RuvB like AAA ATPase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Site Of Double-strand Break H4 Histone Acetyltransferase Complex	Euchromatin Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Dynein Axonemal Particle Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding H4 Histone Acetyltransferase Activity Protein Kinase Binding CAMP Response Element Binding Identical Protein Binding H2B Histone Acetyltransferase Activity Protein-containing Complex Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Protein Binding ATP Binding Beta-catenin Binding ATP Hydrolysis Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity 5'-3' DNA Helicase Activity ADP Binding Unfolded Protein Binding ATPase Binding Promoter-enhancer Loop Anchoring Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development NK T Cell Differentiation Liver Development Positive Regulation Of Protein Phosphorylation Hematopoietic Progenitor Cell Differentiation Outflow Tract Morphogenesis Brainstem Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Vacuole Organization JNK Cascade Response To Water Deprivation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Abducens Nucleus Development Hypoglossal Nucleus Development Facial Nucleus Development Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Oxidative Stress P38MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Histone H4 Acetylation Histone H2B Acetylation Cellular Lipid Metabolic Process Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Neurofilament Cytoskeleton Organization Adipose Tissue Development Motor Neuron Apoptotic Process Amelogenesis Hepatocyte Apoptotic Process Cellular Response To Virus Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Development	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Folding Histone Acetylation DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Circadian Clock Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Heme signaling	Telomere Extension By Telomerase HATs acetylate histones
Drugs		Pseudoephedrine	Quercetin
Diseases
GWAS		Intake of total sugars ( 31005972) Metabolite levels ( 23823483)	Blood protein levels ( 28240269)
Interacting Genes		66 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BANP BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CENPQ CFLAR CREB5 CSNK2A1 CSNK2A2 CYP27B1 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FOS FOSB FOSL1 FOSL2 GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 LHX8 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PIAS2 PML PRKCE RB1 RNF4 RPS6KA5 RUVBL2 SMAD3 SMAD4 SPOPL SRA1 SUMO1 THRB UBE2I USP14 UTF1 XPO1 YY1	33 interacting genes: AGR2 APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DNAJB4 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 MYC NDRG1 OGT RUVBL1 STOM TAF9 TBP TERT TXNIP YWHAQ YY1
Entrez ID		1386	10856
HPRD ID		00443	16070
Ensembl ID		ENSG00000115966	ENSG00000183207
Uniprot IDs		A4D7V5 P15336	B3KNL2 Q9Y230
PDB IDs		1BHI 1T2K 4H36 6ZQS 6ZR5	2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6K0R 6QI8 6QI9 7AHO
Enriched GO Terms of Interacting Partners?
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