MIRLET7G and KARS1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		MIRLET7G	KARS1
Description		microRNA let-7g	lysyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	MRNA Binding Involved In Posttranscriptional Gene Silencing	TRNA Binding ATP Adenylyltransferase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gene Silencing By MiRNA Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Glucose Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Basophil Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Antigenic Stimulus Lysyl-tRNA Aminoacylation TRNA Processing Response To X-ray Diadenosine Tetraphosphate Biosynthetic Process Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade
Pathways			Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs			L-Lysine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 23974872)
Interacting Genes		116 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CCAR1 CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM12B RBM14 RBM17 RBM4 RBM4B RBM5 RBM6 RBMS1 RTCA RTCB SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR	85 interacting genes: AIMP2 CDC42 DARS2 DYSF EEF1D EEF1G ESR1 FRS3 GAPDH GEMIN4 LINC01554 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-2 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 SUMO2 VIM
Entrez ID		406890	3735
HPRD ID			03249
Ensembl ID		ENSG00000199150	ENSG00000065427
Uniprot IDs			Q15046
PDB IDs			3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH
Enriched GO Terms of Interacting Partners?
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