ARL3 and UBR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARL3	UBR1
Description		ADP ribosylation factor like GTPase 3	ubiquitin protein ligase E3 component n-recognin 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Midbody Photoreceptor Connecting Cilium Extracellular Exosome	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding GTPase Activating Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	Mitotic Cytokinesis Kidney Development Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Smoothened Signaling Pathway Small GTPase Mediated Signal Transduction Protein Transport Positive Regulation Of Microtubule Polymerization Intraciliary Transport Photoreceptor Cell Development Cilium Assembly Protein Localization To Cilium Protein Localization To Ciliary Membrane	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Trafficking of myristoylated proteins to the cilium	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		2-(N-morpholino)ethanesulfonic acid Guanosine-5'-Diphosphate
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 30487518) Mean arterial pressure (long-term average) ( 28348047) Prostate cancer ( 23535732) Pulse pressure ( 30487518) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 27922604) Systolic blood pressure ( 30487518) Systolic blood pressure (long-term average) ( 28348047) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		12 interacting genes: ARL2BP GOLGA4 LRIF1 PDE6D PTEN RP2 TBL1X TLE1 TP53 TUBA1A UBR1 UNC119	31 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		403	197131
HPRD ID		05260	09342
Ensembl ID		ENSG00000138175	ENSG00000159459
Uniprot IDs		P36405	Q8IWV7
PDB IDs			3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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