LMAN1 and MCFD2

Number of citations of the paper that reports this interaction (PubMedID 12717434)
75

Data Source:
HPRD (in vivo, in vitro)

		LMAN1	MCFD2
Description		lectin, mannose binding 1	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Sarcomere COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Mannose Binding Metal Ion Binding Unfolded Protein Binding	Calcium Ion Binding Protein Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Blood Coagulation Positive Regulation Of Organelle Organization Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport Negative Regulation Of Protein Targeting To Mitochondrion	Protein Transport Vesicle-mediated Transport
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Transport to the Golgi and subsequent modification	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa	Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Morning vs. evening chronotype ( 27494321)	Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)
Interacting Genes		4 interacting genes: APP F8 MCFD2 OGT	11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1
Entrez ID		3998	90411
HPRD ID		03338	09693
Ensembl ID		ENSG00000074695	ENSG00000180398
Uniprot IDs		A0A024R2A7 P49257	B4DF17 Q8NI22
PDB IDs		3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE	2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE
Enriched GO Terms of Interacting Partners?
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