LIMS1 and CCN2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		LIMS1	CCN2
Description		LIM zinc finger domain containing 1	cellular communication network factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein-containing Complex Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cis-Golgi Network Cytosol Plasma Membrane Cell Cortex Extracellular Matrix Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-containing Complex Binding	Fibronectin Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Protein C-terminus Binding Growth Factor Activity Heparin Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Integrin-mediated Signaling Pathway	Cartilage Condensation Ossification Angiogenesis Tissue Homeostasis Positive Regulation Of Protein Phosphorylation Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Aging Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Cell Migration Cell Differentiation Lung Development Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Response To Anoxia Intracellular Signal Transduction Chondrocyte Proliferation Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Cell Activation Response To Mineralocorticoid Positive Regulation Of Stress Fiber Assembly Cytosolic Calcium Ion Transport Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Death Extracellular Matrix Constituent Secretion Positive Regulation Of G0 To G1 Transition Positive Regulation Of ERK1 And ERK2 Cascade Response To Fatty Acid DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		48 interacting genes: ADAMTS9 ATXN10 CATSPER1 CCN2 COL8A1 CSRP3 CWF19L2 DAPK1 EHMT2 FAM90A1 FERMT2 FERMT3 FMR1 GEM ILK INO80B IPO7 KAT8 KPRP LMO3 LPXN MBIP MYO15B NCK2 NEB OSR2 PARVA PEG3 PLCE1 RAD51D RBBP8 RSU1 SCNM1 SMURF1 TBC1D22B TCEA2 TGFBR1 TMSB4X TRIO TTN USP11 ZIM2 ZMYM4 ZNF160 ZNF410 ZNF417 ZNF564 ZNF587	13 interacting genes: ACTB AP3D1 CCN3 ERBB4 FBLN1 HSPG2 LIMS1 LRP1 MTDH TGFB1 TGFB2 TGFB3 VEGFA
Entrez ID		3987	1490
HPRD ID		03978	00412
Ensembl ID		ENSG00000169756	ENSG00000118523
Uniprot IDs		P48059	P29279 Q5M8T4
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF 7D2S 7D2T 7D2U
Enriched GO Terms of Interacting Partners?
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