LGALS8 and ITGA4

Number of citations of the paper that reports this interaction (PubMedID 10852818)
54

Data Source:
HPRD (in vivo, in vitro)

		LGALS8	ITGA4
Description		galectin 8	integrin subunit alpha 4
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle	Plasma Membrane Focal Adhesion Cell Surface Membrane Growth Cone Integrin Alpha4-beta1 Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome
	Molecular Function	Integrin Binding Protein Binding Carbohydrate Binding	Fibronectin Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Metal Ion Binding Cell Adhesion Molecule Binding Protein Antigen Binding
	Biological Process	Cellular Response To Virus Xenophagy Lymphatic Endothelial Cell Migration	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway B Cell Differentiation Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Import Into Cell Cell-cell Adhesion In Response To Extracellular Stimulus Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration Potential therapeutics for SARS
Drugs			Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab MK-0668
Diseases
GWAS		Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 23314186 28193307 25096241 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Monocyte-lymphocyte ratio ( 28193307) Multiple sclerosis ( 24076602) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) Ulcerative colitis ( 28067908) White blood cell count ( 29403010 32888494 21738480) White blood cell count (basophil) ( 29403010) White blood cell count (monocyte) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		21 interacting genes: APEH BARD1 CALCOCO2 ERBB2 ITGA3 ITGA4 ITGB1 LRRK2 MEFV MID2 NACC1 NR1D2 TAX1BP1 TNFRSF18 TRIM17 TRIM22 TRIM23 TRIM49 TRIM5 TRIM6 WBP2	16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN
Entrez ID		3964	3676
HPRD ID		09356	01894
Ensembl ID		ENSG00000116977	ENSG00000115232
Uniprot IDs		O00214	P13612
PDB IDs		2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y	3V4P 3V4V 4HKC 5C7Z 5FPI
Enriched GO Terms of Interacting Partners?
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