LCP2 and PRAM1

Number of citations of the paper that reports this interaction (PubMedID 11301322)
17

Data Source:
HPRD (in vivo, in vitro)

		LCP2	PRAM1
Description		lymphocyte cytosolic protein 2	PML-RARA regulated adaptor molecule 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Protein Kinase Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Integrin-mediated Signaling Pathway Regulation Of Neutrophil Degranulation T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Coronary artery disease ( 29212778) Height ( 18391951)
Interacting Genes		50 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GALNT10 GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	25 interacting genes: A2M ABI2 APOE APP BCAR1 CCDC57 CDC37 FXR1 FXR2 GOLGA2 KRT40 LCP2 LYN MAST1 MXD1 NEDD9 NEK6 PSEN1 RNF32 SH3RF1 SKAP1 SKAP2 TP53BP2 TRIM27 UBE2E2
Entrez ID		3937	84106
HPRD ID		03362	05926
Ensembl ID		ENSG00000043462	ENSG00000133246
Uniprot IDs		Q13094	Q96QH2
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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