LCP2 and TXK

Number of citations of the paper that reports this interaction (PubMedID 8702662)
91

Data Source:
HPRD (in vitro, in vivo)

		LCP2	TXK
Description		lymphocyte cytosolic protein 2	TXK tyrosine kinase
Image
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Positive Regulation Of Cytokine Production Adaptive Immune Response Protein Phosphorylation Activation Of Phospholipase C Activity Integrin-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Platelet Activation Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Aspartate aminotransferase levels ( 33547301) Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494 27863252)
Interacting Genes		50 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GALNT10 GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	40 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TEC TNS4 UTP18 YTHDC1 ZNF587 ZNF792 ZNF835
Entrez ID		3937	7294
HPRD ID		03362	02505
Ensembl ID		ENSG00000043462	ENSG00000074966
Uniprot IDs		Q13094	P42681
PDB IDs		1H3H 1YWO 2EAP 2ROR	2DM0
Enriched GO Terms of Interacting Partners?
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