LCN1 and RECK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LCN1	RECK
Description		lipocalin 1	reversion inducing cysteine rich protein with kazal motifs
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Chloride Ion Binding Small Molecule Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Retina Homeostasis Proteolysis Negative Regulation Of Endopeptidase Activity Response To Stimulus Sensory Perception Of Taste	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways		Transport of fatty acids	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Tretinoin
Diseases
GWAS		Subcutaneous adipose tissue ( 29178545) Subcutaneous adipose tissue (sex interaction) ( 29178545)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		9 interacting genes: ALOX5 FAM25A FAM25C FAM25G LMBR1L LTF LYZ RECK UBQLN2	44 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL RPS6KA1 SIGMAR1 SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		3933	8434
HPRD ID		01059	05567
Ensembl ID		ENSG00000160349	ENSG00000122707
Uniprot IDs		A0A024R8D7 P31025	A8K9D8 O95980 Q6P9E2
PDB IDs		1XKI 3EYC 4QAF 5T43
Enriched GO Terms of Interacting Partners?
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