LAMA5 and MEP1A

Number of citations of the paper that reports this interaction (PubMedID 10620696)
20

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		LAMA5	MEP1A
Description		laminin subunit alpha 5	meprin A subunit alpha
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Exosome
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Integrin-mediated Signaling Pathway Axon Guidance Muscle Organ Development Animal Organ Morphogenesis Tissue Development Morphogenesis Of Embryonic Epithelium Cell Migration Regulation Of Cell Adhesion Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Cell-cell Adhesion	Proteolysis
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling
Drugs		Lanoteplase
Diseases
GWAS		Blood protein levels ( 29875488) Colorectal cancer ( 25990418 20972440 24737748) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Neuroblastoma (pediatric) ( 32599975) Pelvic organ prolapse ( 26545240) Plateletcrit ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		17 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 EDN3 FBLN2 HOXA1 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4	18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		3911	4224
HPRD ID		03020	02666
Ensembl ID		ENSG00000130702	ENSG00000112818
Uniprot IDs		O15230	B7ZL91 Q16819
PDB IDs		5XAU
Enriched GO Terms of Interacting Partners?
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