LAMA5 and LAMC1

Number of citations of the paper that reports this interaction (PubMedID 26344197)
178

Data Source:
BioGRID (biochemical, imaging technique)
HPRD (in vitro)

		LAMA5	LAMC1
Description		laminin subunit alpha 5	laminin subunit gamma 1
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Integrin-mediated Signaling Pathway Axon Guidance Muscle Organ Development Animal Organ Morphogenesis Tissue Development Morphogenesis Of Embryonic Epithelium Cell Migration Regulation Of Cell Adhesion Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Cell-cell Adhesion	Cell Adhesion Endoderm Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Disassembly Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Positive Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Lanoteplase	Lanoteplase
Diseases
GWAS		Blood protein levels ( 29875488) Colorectal cancer ( 25990418 20972440 24737748) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Neuroblastoma (pediatric) ( 32599975) Pelvic organ prolapse ( 26545240) Plateletcrit ( 32888494) Prostate cancer ( 23535732)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) HDL cholesterol levels ( 32203549) Height ( 31562340) Hemoglobin ( 32888494) Hypertriglyceridemia ( 27599772) LDL cholesterol levels in HIV infection ( 33109212) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463)
Interacting Genes		17 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 EDN3 FBLN2 HOXA1 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4	16 interacting genes: ANTXR2 APP ATF7IP CENPU KEAP1 LAMA5 NID1 NID2 PSMC5 SMARCA2 SNAPIN SNX2 SRPK1 TANK UBC WASHC3
Entrez ID		3911	3915
HPRD ID		03020	01030
Ensembl ID		ENSG00000130702	ENSG00000135862
Uniprot IDs		O15230	P11047 Q6NVY8
PDB IDs		5XAU	5XAU
Enriched GO Terms of Interacting Partners?
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