KMT5A and DTL

Number of citations of the paper that reports this interaction (PubMedID 20932471)
138

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		KMT5A	DTL
Description		lysine methyltransferase 5A	denticleless E3 ubiquitin protein ligase homolog
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Cytosol	Nucleus Nucleoplasm Chromosome Nucleolus Centrosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific)	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Chromosome Condensation Peptidyl-lysine Monomethylation Histone H4-K20 Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Signal Transduction By P53 Class Mediator	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Response To UV Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Translesion Synthesis Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Cell Cycle
Pathways		Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation	Recognition of DNA damage by PCNA-containing replication complex Neddylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)	Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379) Plateletcrit ( 32888494)
Interacting Genes		11 interacting genes: BTRC DTL E2F2 FAM9A H4-16 PCNA TCF7L2 TP53 TWIST1 UBE2I USP17L2	18 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 CUL4B DDB1 KAT2A KMT5A PCNA POLD4 RBX1 TDG TOB1 TP53 UBE2D1 UBE2N
Entrez ID		387893	51514
HPRD ID		06254	17952
Ensembl ID		ENSG00000183955	ENSG00000143476
Uniprot IDs		E3VVS3 Q9NQR1	B4E0E6 Q9NZJ0
PDB IDs		1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ 7D1Z 7D20	6QC0
Enriched GO Terms of Interacting Partners?
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