KMT5A and USP17L2

Number of citations of the paper that reports this interaction (PubMedID 31533987)
6

Data Source:
BioGRID (pull down, enzymatic study)

		KMT5A	USP17L2
Description		lysine methyltransferase 5A	ubiquitin specific peptidase 17 like family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Cytosol	Nucleus Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific)	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Chromosome Condensation Peptidyl-lysine Monomethylation Histone H4-K20 Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Signal Transduction By P53 Class Mediator	MAPK Cascade Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Negative Regulation Of Protein Processing Protein Deubiquitination Regulation Of Cell Migration Negative Regulation Of Histone Deacetylation Negative Regulation Of GTPase Activity Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Defense Response To Virus By Host Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation	Ub-specific processing proteases RAS processing
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		11 interacting genes: BTRC DTL E2F2 FAM9A H4-16 PCNA TCF7L2 TP53 TWIST1 UBE2I USP17L2	9 interacting genes: BRD4 CDK4 CDK6 ELK1 KMT5A LGMN LINC02487 SNAI1 UBC
Entrez ID		387893	377630
HPRD ID		06254	16844
Ensembl ID		ENSG00000183955	ENSG00000223443
Uniprot IDs		E3VVS3 Q9NQR1	Q6R6M4
PDB IDs		1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ 7D1Z 7D20
Enriched GO Terms of Interacting Partners?
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