KRTAP12-3 and PDGFRB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KRTAP12-3	PDGFRB
Description		keratin associated protein 12-3	platelet derived growth factor receptor beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Intrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Lysosomal Lumen Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Enzyme Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Phosphatidylinositol 3-kinase Binding Platelet-derived Growth Factor Binding
	Biological Process		Angiogenesis Glycosaminoglycan Biosynthetic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Aging Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Response To Estradiol Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Kinase Activity Response To Fluid Shear Stress Positive Regulation Of Rho Protein Signal Transduction Cell Migration Involved In Vasculogenesis Metanephric Mesenchymal Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Mitotic Nuclear Division Phosphatidylinositol Metabolic Process Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Inner Ear Development Positive Regulation Of Chemotaxis Cardiac Myofibril Assembly Response To Hyperoxia Cell Chemotaxis Lung Growth Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Mesenchyme Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of DNA Biosynthetic Process
Pathways		Keratinization	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Becaplermin Sorafenib Imatinib Dasatinib Sunitinib XL999 XL820 Pazopanib Midostaurin Regorafenib Nintedanib Polaprezinc Trapidil Foreskin fibroblast (neonatal) Fostamatinib Erdafitinib Pexidartinib Ripretinib Pralsetinib
Diseases
GWAS			Blood protein levels ( 30072576 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252)
Interacting Genes		142 interacting genes: ADAMTSL3 ADAMTSL4 AGXT ALDH3B1 BCL6B BMP7 C11orf87 C22orf39 CARD10 CATSPER1 CBX2 CELF5 CHIC2 CHRD CHRNG CNNM3 COL8A1 CRCT1 CREB5 CYSRT1 DALRD3 DHRS1 DHX57 DNAL4 DOCK2 FASLG FBXW5 GLRX3 GNE GTF3C5 HOXA1 ITGB4 JOSD1 KPRP KRT20 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP19-7 KRTAP3-3 KRTAP4-2 KRTAP4-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIF LMNTD2 LNX1 LYVE1 MAPKBP1 MEOX2 MISP MOBP NBPF19 NKD1 NMU NOTCH2NLA NPDC1 NR1D2 NR4A3 NUFIP2 OTX1 OXER1 P2RX4 P2RY6 P3H3 P4HB PDE9A PDGFRB PGAP6 PHLDA1 POU4F2 PTGDS PTPMT1 R3HDM2 RSPO2 SELENOM SHFL SLC13A5 SLC15A2 SLC23A1 SPATA3 SPRY1 TCEA2 TCEANC TFAP2D TMIE TNP2 TNS2 TTPA UTP23 UXT VASN VGLL3 VSTM4 WDR25 WNT11 YY1 ZDHHC1 ZNF101 ZNF124 ZNF138 ZNF20 ZNF408 ZNF417 ZNF439 ZNF440 ZNF467 ZNF490 ZNF491 ZNF497 ZNF578 ZNF587 ZNF648 ZNF696 ZNF80 ZNF835 ZNF837 ZSCAN21	84 interacting genes: ABL1 ABL2 ARAF BAG1 CAV1 CAV3 CBL CDK14 CDX1 CEP76 CHRM3 COPA COPB1 CRK EGFR EIF2AK2 ERBB2 FAXDC2 FGFR1 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 ITK JAK1 JAK2 KLHL12 KPRP KRT31 KRT34 KRTAP10-9 KRTAP12-3 KRTAP4-12 MITF NCK1 NCK2 NEDD4 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PPM1L PRDX2 PTEN PTK2 PTPN1 PTPN11 PTPN2 PTPN6 PTPRJ RAF1 RASA1 RPS6KB2 S1PR1 SHC1 SLC9A3R1 SLC9A3R2 SNX1 SNX2 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TNK2 TPTE TRIP6 TUFM TYK2 VAV1 YES1
Entrez ID		386683	5159
HPRD ID		11199	01423
Ensembl ID		ENSG00000205439	ENSG00000113721
Uniprot IDs		P60328	P09619 Q59F04
PDB IDs			1GQ5 1H9O 1LWP 1SHA 2IUI 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?
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