Description |
KRAS proto-oncogene, GTPase |
Raf-1 proto-oncogene, serine/threonine kinase |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Alanine aminotransferase levels ( 33547301)
- Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
- Dysmenorrheic pain ( 27454463)
- Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
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- Asthma ( 32296059)
- Body shape index ( 34021172)
- Cardiac hypertrophy ( 21348951)
- Carotid intima media thickness x smoking interaction ( 32117412)
- Cholesterol, total ( 24097068 20686565)
- Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
- HDL cholesterol levels ( 32203549)
- Hip index ( 34021172)
- Total cholesterol levels ( 28334899)
- Waist circumference adjusted for body mass index ( 34021172)
- Waist-hip index ( 34021172)
- Waist-to-hip ratio adjusted for BMI ( 34021172 26426971)
- Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
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Interacting Genes |
61 interacting genes:
ADH6
ARL6IP5
BCAS3
BCL2
CALM1
CCL5
CCT7
CDK8
DDX47
DDX50
DIRAS3
DNAJA3
EGLN1
EPB42
FANCC
FNTA
FNTB
FRAT2
HEMGN
HNRNPC
HRAS
IGFBP3
IGSF21
IL24
LPAR1
LYPD4
LZTR1
MDFI
MOCS2
MT-CO3
MT-CYB
NDUFA13
OSGIN1
PDE4DIP
PGGT1B
PIK3CA
PIK3CG
PIK3R2
PIP5K1A
PPP2CB
PSMA3
QDPR
RAF1
RALGDS
RAP1GDS1
RASGRF2
RASGRP2
RASSF2
RASSF5
RBPMS
RGL2
SERPINB5
SHOC2
SOX4
STX17
THRSP
TNFSF13
UQCRC1
WDR76
ZDHHC17
ZNF189
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160 interacting genes:
ABCB5
ADCY6
AGTR1
AKT1
AR
ARNT
ARRB2
BAD
BAG1
BCL2
BCL2L1
BCL6
BECN1
BIRC2
BIRC3
BRAF
CASZ1
CBLC
CCND2
CCT3
CD44
CDC25A
CDC37
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CFLAR
CNKSR1
COPS3
COPS7A
CPS1
DCAF8
DMPK
EFEMP1
EGFR
EPHA2
ERBB2
ERBIN
FGFR4
FYCO1
FYN
GLIS2
GNB2
GNG4
GRB10
GRM1
HERC1
HGF
HRAS
HSP90AA1
HSPA4
HSPA8
IL2RB
INSR
INTS10
ITCH
JAK1
JAK2
KEAP1
KRAS
KRT18
KRT8
KSR1
KSR2
LATS2
LCK
LOX
LRPAP1
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MAP2K6
MAP3K1
MAP3K5
MAPK1
MAPK3
MAPK7
MAPK8
MAPK8IP3
MBP
MET
MRAS
MRC2
MYBPC1
MYC
NEDD4
NF1
NF2
NPLOC4
NR3C1
NRAS
NUDT14
OIP5
PACSIN3
PAK1
PAK2
PAK3
PBK
PDGFRA
PDGFRB
PDLIM2
PEBP1
PEBP4
PEX5L
PHB
PHKA2
PIN1
PKM
PPP1CC
PPP2CB
PRKAA1
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCE
PRKCZ
PRKG1
PRPF6
PURA
RANBP9
RAP1A
RAP2A
RASD2
RASSF1
RB1
RBBP8
RBL2
RFXANK
RHEB
RRAS
RRAS2
RSU1
SHOC2
SPRY2
SPRY4
SRC
STK26
STK3
STUB1
TBXA2R
TEAD2
TERT
TIMM50
TMEM70
TSC22D3
UBE2D2
VAV1
VDAC1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
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Entrez ID |
3845 |
5894 |
HPRD ID |
01817 |
01265 |
Ensembl ID |
ENSG00000133703
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ENSG00000132155
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Uniprot IDs |
A0A024RAV5
I1SRC5
L7RSL8
P01116
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A0A0S2Z4L5
L7RRS6
P04049
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PDB IDs |
1D8D
1D8E
1KZO
1KZP
1N4P
1N4Q
1N4R
1N4S
2MSC
2MSD
2MSE
3GFT
4DSN
4DSO
4EPR
4EPT
4EPV
4EPW
4EPX
4EPY
4L8G
4LDJ
4LPK
4LRW
4LUC
4LV6
4LYF
4LYH
4LYJ
4M1O
4M1S
4M1T
4M1W
4M1Y
4M21
4M22
4NMM
4OBE
4PZY
4PZZ
4Q01
4Q02
4Q03
4QL3
4TQ9
4TQA
4WA7
5F2E
5KYK
5MLA
5MLB
5O2S
5O2T
5OCG
5OCO
5OCT
5TAR
5TB5
5UFE
5UFQ
5UK9
5UQW
5US4
5USJ
5V6S
5V6V
5V71
5V9L
5V9O
5V9U
5VBM
5VP7
5VPI
5VPY
5VPZ
5VQ0
5VQ1
5VQ2
5VQ6
5VQ8
5W22
5WHA
5WHB
5WHD
5WHE
5WLB
5WPM
5XCO
5YXZ
5YY1
6ARK
6ASA
6ASE
6B0V
6B0Y
6BOF
6BP1
6CC9
6CCH
6CCX
6CU6
6E6F
6E6G
6EPL
6EPM
6EPN
6EPO
6EPP
6F76
6FA1
6FA2
6FA3
6FA4
6GJ5
6GJ6
6GJ7
6GJ8
6GOD
6GOE
6GOF
6GOG
6GOM
6GQT
6GQW
6GQX
6GQY
6H46
6H47
6JTN
6JTO
6JTP
6M9W
6MBQ
6MBT
6MBU
6MNX
6MQG
6MQN
6MS9
6MTA
6N2J
6N2K
6O36
6O46
6O4Y
6O4Z
6O51
6O53
6OB2
6OB3
6OIM
6P0Z
6P8W
6P8X
6P8Y
6P8Z
6PGO
6PGP
6PQ3
6PTS
6PTW
6QUU
6QUV
6QUW
6QUX
6T5B
6T5U
6T5V
6TAM
6TAN
6USX
6USZ
6UT0
6V5L
6V65
6V6F
6VC8
6VJJ
6W4E
6W4F
6WGN
6XGU
6XGV
6XHA
6XHB
6YR8
6YXW
6ZL5
6ZLI
7ACA
7ACF
7ACH
7ACQ
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1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8
3IQJ
3IQU
3IQV
3KUC
3KUD
3NKX
3O8I
3OMV
4FJ3
4G0N
4G3X
4IEA
4IHL
6NTC
6NTD
6PTS
6PTW
6VJJ
6XGU
6XGV
6XHA
6XHB
6XI7
7JHP
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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