KIF11 and DCTN1

Number of citations of the paper that reports this interaction (PubMedID 9235942)
54

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		KIF11	DCTN1
Description		kinesin family member 11	dynactin subunit 1
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Spindle Cytosol Kinesin Complex Microtubule Spindle Microtubule Membrane Protein-containing Complex Mitotic Spindle	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Microtubule Plus-end Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Protein Kinase Binding	Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding Microtubule Plus-end Binding
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Mitotic Centrosome Separation Regulation Of Mitotic Centrosome Separation Cell Division Mitotic Spindle Assembly	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Migration Nervous System Development Neuromuscular Junction Development Centriole-centriole Cohesion Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Membrane Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants
Drugs		3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol Monastrol Filanesib (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE MK-0731 [(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE
Diseases
GWAS		Asthma ( 30929738 32296059 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood glucose levels ( 31928498) Inflammatory bowel disease ( 28067908) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29785010 30054594) Pancreatic beta-cell glucose sensitivity ( 32944759) Triglyceride levels ( 31928498) Type 2 diabetes ( 21490949 31118516)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: AURKA CDK1 DCTN1 ERCC1 ERCC4 PKD2 PPARG RNF20 RNF40 SRPK2 SUMO2	51 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 ENO3 FBXL5 FXR1 GRB2 GSK3B HAP1 HOXA1 HSPB2 KIAA0408 KIF11 KMT2A KRT5 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TMED5 TP53RK VIM ZNF512B
Entrez ID		3832	1639
HPRD ID		01023	07206
Ensembl ID		ENSG00000138160	ENSG00000204843
Uniprot IDs		P52732	Q14203 Q6MZZ3
PDB IDs		1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3WPN 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B 4BBG 4BXN 4CK5 4CK6 4CK7 4ZCA 4ZHI 5JV3 5ZO7 5ZO8 5ZO9 6G6Y 6G6Z 6HKX 6HKY 6TA3 6TA4 6TIW	1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?
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