KHK and LHX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KHK	LHX2
Description		ketohexokinase	LIM homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Ketohexokinase Activity Protein Binding ATP Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Metal Ion Binding
	Biological Process	Fructose Metabolic Process Response To Sucrose Response To Glucose Response To Fructose Response To Zinc Ion Response To Insulin Carbohydrate Phosphorylation Regulation Of Glycogen Metabolic Process	Neural Tube Closure Hair Follicle Development Regulation Of Transcription By RNA Polymerase II Axon Guidance Mesoderm Development Dorsal/ventral Pattern Formation Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Essential fructosuria Fructose catabolism	Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		4 interacting genes: APPBP2 GLP1R LHX2 LHX9	29 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L ENG FLYWCH1 HOMER3 HOXC8 KHK LDB1 LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511
Entrez ID		3795	9355
HPRD ID		11774	04786
Ensembl ID		ENSG00000138030	ENSG00000106689
Uniprot IDs		A0A140VJM6 P50053	B3KNJ5 P50458
PDB IDs		2HLZ 2HQQ 2HW1 3B3L 3NBV 3NBW 3NC2 3NC9 3NCA 3Q92 3QA2 3QAI 3RO4 5WBM 5WBO 5WBP 5WBQ 5WBR 5WBZ 6W0N 6W0W 6W0X 6W0Y 6W0Z
Enriched GO Terms of Interacting Partners?
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