NHLRC1 and AGL

Number of citations of the paper that reports this interaction (PubMedID 17908927)
48

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NHLRC1	AGL
Description		NHL repeat containing E3 ubiquitin protein ligase 1	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Cytoplasm Cytosol Inclusion Body Sarcoplasmic Reticulum Secretory Granule Lumen Isoamylase Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Glycogen Debranching Enzyme Activity 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Protein Binding Polysaccharide Binding Polyubiquitin Modification-dependent Protein Binding Beta-maltose 4-alpha-glucanotransferase Activity
	Biological Process	Protein Polyubiquitination Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Localization To Plasma Membrane	Glycogen Biosynthetic Process Glycogen Catabolic Process Response To Nutrient Response To Glucocorticoid
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs
Diseases
GWAS		Intrinsic epigenetic age acceleration ( 29374233)	Carotid intima media thickness ( 26343869) Incident chronic kidney disease ( 30955190) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		8 interacting genes: AGL GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H	3 interacting genes: APPL1 NHLRC1 PRKAB1
Entrez ID		378884	178
HPRD ID		06995	01984
Ensembl ID		ENSG00000187566	ENSG00000162688
Uniprot IDs		Q6VVB1	A0A0S2A4E4 P35573
PDB IDs
Enriched GO Terms of Interacting Partners?
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