ITK and DOK1

Number of citations of the paper that reports this interaction (PubMedID 22974441)
11

Data Source:
BioGRID (unspecified method)

		ITK	DOK1
Description		IL2 inducible T cell kinase	docking protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation Gamma-delta T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Macrophage Colony-stimulating Factor Signaling Pathway
Pathways		Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling
Drugs		Staurosporine Pazopanib Fostamatinib Zanubrutinib
Diseases
GWAS		Asthma ( 31959851 34103634) Daytime sleep phenotypes ( 27126917) Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Bell's palsy ( 33602968) Height ( 31562340)
Interacting Genes		35 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FGFR1 FYN GAB1 GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 MET PDGFRB PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS	42 interacting genes: ABL1 ABL2 BCR CRK CRKL CSDE1 CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1
Entrez ID		3702	1796
HPRD ID		01746	04228
Ensembl ID		ENSG00000113263	ENSG00000115325
Uniprot IDs		Q08881	B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM	2V76
Enriched GO Terms of Interacting Partners?
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