ITIH4 and KLK1

Number of citations of the paper that reports this interaction (PubMedID 3643793)
29

Data Source:
BioGRID (pull down)

		ITIH4	KLK1
Description		inter-alpha-trypsin inhibitor heavy chain 4	kallikrein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Nucleus Secretory Granule Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity
	Biological Process	Acute-phase Response Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Response To Cytokine	Regulation Of Systemic Arterial Blood Pressure Zymogen Activation
Pathways		Platelet degranulation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Blood protein levels ( 30072576) Body mass index ( 28552196 24861553) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-2) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Manganese levels ( 26025379) Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 28892059) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 21926974 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 23128233) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		4 interacting genes: DNAJC1 GRB2 KLK1 TP63	8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1
Entrez ID		3700	3816
HPRD ID		02781	01003
Ensembl ID		ENSG00000055955	ENSG00000167748
Uniprot IDs		B2RMS9 B7ZKJ8 Q14624	A0A1L2BPJ2 A0A1R3UCD2 P06870
PDB IDs			1SPJ
Enriched GO Terms of Interacting Partners?
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