INPP4A and CAPN1

Number of citations of the paper that reports this interaction (PubMedID 9110986)
15

Data Source:
HPRD (in vivo, in vitro)

		INPP4A	CAPN1
Description		inositol polyphosphate-4-phosphatase type I A	calpain 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Early Endosome Membrane Nuclear Membrane Recycling Endosome Membrane	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Phosphatidylinositol-3,4-bisphosphate 4-phosphatase Activity Inositol-1,3,4-trisphosphate 4-phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Inositol-3,4-bisphosphate 4-phosphatase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Dephosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis Regulation Of NMDA Receptor Activity
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of IP2, IP, and Ins in the cytosol	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984)	Urate levels ( 31578528)
Interacting Genes		3 interacting genes: CAPN1 PIK3R1 SMAD1	58 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BBS9 BCL2L1 BID CAPNS1 CASP14 CAST CBL CD5 CDK4 CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 ELOB F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		3631	823
HPRD ID		02949	00253
Ensembl ID		ENSG00000040933	ENSG00000014216
Uniprot IDs		D3DVH3 Q96PE3	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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