CAPN1 and UFSP2

Number of citations of the paper that reports this interaction (PubMedID 12358155)
5

Data Source:
HPRD (two hybrid)

		CAPN1	UFSP2
Description		calpain 1	UFM1 specific peptidase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Endoplasmic Reticulum
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity	Protein Binding Thiolester Hydrolase Activity UFM1 Hydrolase Activity
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis Regulation Of NMDA Receptor Activity	Proteolysis Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Urate levels ( 31578528)
Interacting Genes		58 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BBS9 BCL2L1 BID CAPNS1 CASP14 CAST CBL CD5 CDK4 CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 ELOB F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	4 interacting genes: APOBEC1 CAPN1 LIG4 LMO1
Entrez ID		823	55325
HPRD ID		00253	07741
Ensembl ID		ENSG00000014216	ENSG00000109775
Uniprot IDs		B2RDI5 B4DWH5 P07384	B3KRI4 Q9NUQ7
PDB IDs		1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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