IMPA2 and UBA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		IMPA2	UBA3
Description		inositol monophosphatase 2	ubiquitin like modifier activating enzyme 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Inositol Monophosphate 1-phosphatase Activity Protein Homodimerization Activity Metal Ion Binding Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity	Protein Binding ATP Binding Nuclear Receptor Binding NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Inositol Metabolic Process Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process Inositol Phosphate Dephosphorylation	Cellular Protein Modification Process Proteolysis Endomitotic Cell Cycle Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Lithium cation Lithium citrate Lithium succinate Lithium carbonate
Diseases
GWAS		Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Hemoglobin ( 32888494) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Stroke ( 17434096)	Meat-related diet ( 32066663)
Interacting Genes		6 interacting genes: CCT6A HERPUD1 IMPA1 SLC44A3 TNFRSF14 UBA3	13 interacting genes: CHD3 CPNE2 DUSP23 IMPA2 KDM1A NAE1 NEDD8 OGT TRIM55 TRIM63 UBE2D2 UBE2F UBE2M
Entrez ID		3613	9039
HPRD ID		09329	04413
Ensembl ID		ENSG00000141401	ENSG00000144744
Uniprot IDs		O14732	Q8TBC4
PDB IDs		2CZH 2CZI 2CZK 2DDK 2FVZ	1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM
Enriched GO Terms of Interacting Partners?
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