AQP4 and AP2M1

Number of citations of the paper that reports this interaction (PubMedID 11742978)
41

Data Source:
HPRD (in vitro)

		AQP4	AP2M1
Description		aquaporin 4	adaptor related protein complex 2 subunit mu 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Sarcolemma Astrocyte End-foot	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Water Channel Activity	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Renal Water Homeostasis Water Transport Cellular Water Homeostasis Water Homeostasis Multicellular Organismal Water Homeostasis Protein Homotetramerization Transmembrane Transport Cellular Response To Interferon-gamma Cerebrospinal Fluid Circulation	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Vesicle-mediated Transport Receptor Internalization Cellular Protein-containing Complex Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Metabolite levels ( 23823483)	Major depressive disorder ( 22472876)
Interacting Genes		7 interacting genes: AP2M1 AP3M1 CREB3 CSNK2A1 CSNK2A2 GJA8 HPCAL4	87 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD3D CDK11B CKS1B CORO7 CRIP1 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DNAJB11 DPPA2 DVL2 EAF1 EHD2 EIF1AD EIF4G1 ETV5 FAM90A1 FGF12 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HTR6 IKZF1 IL1RAP JADE1 KCNJ11 KNOP1 LAMP1 LPP LTB4R2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TMA16 UBC UTP25 XPA ZBTB8A ZNF581
Entrez ID		361	1173
HPRD ID		02631	03014
Ensembl ID		ENSG00000171885	ENSG00000161203
Uniprot IDs		A0A5F9ZHR4 F1DSG4 P55087 V9PBN7	B4DNB9 E9PFW3 Q96CW1
PDB IDs		3GD8	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?
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