IL16 and DUSP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IL16	DUSP7
Description		interleukin 16	dual specificity phosphatase 7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Focal Adhesion Nuclear Speck Flemming Body	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cytokine Activity CD4 Receptor Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Immune Response Signal Transduction Leukocyte Chemotaxis Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Regulation Of Calcium Ion Transport	MAPK Cascade Peptidyl-tyrosine Dephosphorylation Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade
Pathways		Other interleukin signaling	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Brown vs. black hair color ( 30531825) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Height ( 31562340) Inattentive symptoms ( 18821565) Interleukin-16 levels ( 27989323) Lymphocyte counts ( 32888494) Primary biliary cholangitis ( 28425483)
Interacting Genes		109 interacting genes: ANXA6 BLZF1 BOLA2 BOLA2B CALCOCO2 CAMK1 CARD10 CASP3 CCDC184 CCDC33 CD4 CDK1 CEP72 CSNK2A1 CSNK2A2 CYSRT1 DMRTB1 DUSP7 EFEMP2 FAM124A FHL2 FHL5 FTO GABPB1 GOLGA2 GOLGA6L9 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 HOMEZ HOOK2 HSF2BP JAKMIP1 KANK2 KCNA3 KCND1 KCND2 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KCTD9 KDM1A KIF16B KIFC3 KRT31 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP3-1 L3MBTL3 LGALS14 LMO3 LNX1 LNX2 MBD3L1 MID2 MIER2 MTUS2 MYOG NOXA1 NTAQ1 OIP5 PCSK6 PDLIM7 PFDN5 PICK1 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PRDM6 PRR13 PSTPIP1 RAPGEF2 RBCK1 RNF144B SERTAD3 SMARCB1 SOHLH1 SPRED1 SUV39H1 TEPSIN TFIP11 TRIB3 TRIM23 TRIM27 TRIM42 TRIP6 UBXN11 USHBP1 WWTR1 ZBTB39 ZIM2 ZNF143 ZNF165 ZNF474 ZNF526 ZNF572 ZNF581 ZNF620 ZNF774 ZNF777 ZNF835 ZNRD2 ZRANB1	8 interacting genes: CCR1 EEF1A1 EGLN3 GHR IL16 MAPK1 MAPK14 MAPK8
Entrez ID		3603	1849
HPRD ID		04329	04125
Ensembl ID		ENSG00000172349	ENSG00000164086
Uniprot IDs		Q14005 Q9UME6	Q16829
PDB IDs		1I16 1X6D 5FB8	4Y2E
Enriched GO Terms of Interacting Partners?
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