IL12A and CD28

Number of citations of the paper that reports this interaction (PubMedID 7516408)
64

Data Source:
HPRD (in vivo, in vitro)

		IL12A	CD28
Description		interleukin 12A	CD28 molecule
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Late Endosome Lumen Interleukin-12 Complex	Immunological Synapse Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Protein Complex Involved In Cell Adhesion
	Molecular Function	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity	Protease Binding Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Regulation Of Cell Cycle Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Dendritic Cell Chemotaxis	Positive Regulation Of Cytokine Production Positive Regulation Of Inflammatory Response To Antigenic Stimulus Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of T Cell Proliferation T Cell Activation Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes T Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling	PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 23291587 27548383 25799145) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 25920553 18311140) Limited cutaneous systemic scleroderma ( 24387989) Major depressive disorder ( 23377640) Multiple sclerosis ( 24076602 19525953 21833088) Primary biliary cholangitis ( 28425483 19458352 21399635 20639880 26394269 28062665) Primary biliary cirrhosis ( 22961000) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic sclerosis ( 24387989 31672989)	Alopecia areata ( 25608926) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 21841780) Heschl's gyrus morphology ( 25130324) Inflammatory bowel disease ( 26192919) Lymphocyte counts ( 32888494) Multiple sclerosis ( 31604244 24076602) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 23603763 27992413) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 26192919)
Interacting Genes		5 interacting genes: CD28 CXCL8 EBI3 IL12B WASF1	25 interacting genes: AP1M1 BCS1L CAND1 CD247 CD4 CD80 CD86 CFLAR CTLA4 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC SEC14L2 WBP2NL YAP1
Entrez ID		3592	940
HPRD ID		01193	01727
Ensembl ID		ENSG00000168811	ENSG00000178562
Uniprot IDs		O60595 P29459	B4E0L1 P10747
PDB IDs		1F45 3HMX	1YJD 3WA4 5AUL 5GJH 5GJI 6O8D
Enriched GO Terms of Interacting Partners?
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