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CD28 and PIK3R2
Number of citations of the paper that reports this interaction (PubMedID
7509360
)
43
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
CD28
PIK3R2
Description
CD28 molecule
phosphoinositide-3-kinase regulatory subunit 2
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Protein Complex Involved In Cell Adhesion
Nucleus
Cytosol
Phosphatidylinositol 3-kinase Complex
Molecular Function
Protease Binding
Protein Binding
Coreceptor Activity
Protein Kinase Binding
Identical Protein Binding
Phosphotyrosine Residue Binding
Protein Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Biological Process
Positive Regulation Of Cytokine Production
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Humoral Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of T Cell Proliferation
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Thymic T Cell Selection
Regulatory T Cell Differentiation
Positive Regulation Of Viral Genome Replication
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
Cellular Glucose Homeostasis
Insulin Receptor Signaling Pathway
Regulation Of Autophagy
Phosphatidylinositol 3-kinase Signaling
Protein Transport
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of MAPK Cascade
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Phosphatidylinositol Phosphate Biosynthetic Process
Pathways
PIP3 activates AKT signaling
Nef mediated downregulation of CD28 cell surface expression
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Drugs
Isoprenaline
SF1126
Diseases
GWAS
Alopecia areata (
25608926
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Graves' disease (
21841780
)
Heschl's gyrus morphology (
25130324
)
Inflammatory bowel disease (
26192919
)
Lymphocyte counts (
32888494
)
Multiple sclerosis (
31604244
24076602
)
Primary biliary cholangitis (
28425483
)
Primary sclerosing cholangitis (
23603763
27992413
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Subcutaneous adipose tissue (
29178545
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
26192919
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Interacting Genes
25 interacting genes:
AP1M1
BCS1L
CAND1
CD247
CD4
CD80
CD86
CFLAR
CTLA4
DUSP14
GRAP2
GRB2
IL12A
ITK
LCK
LRRC23
NSF
PIK3CG
PIK3R1
PIK3R2
PLCG1
PTPRC
SEC14L2
WBP2NL
YAP1
59 interacting genes:
APP
APPL1
AR
ARRB1
AXL
CBL
CD28
CRK
CRKL
CSF1R
DYDC1
EGF
EGFR
ENKUR
EPHA2
ERBB2
ERBB3
ERBB4
FBXL2
FGFR1
FYN
GAB1
GHR
GOLGA2
GRB2
GRN
HCK
IGF1R
IKZF3
IRS1
IRS2
KIT
KRAS
KRT15
KRT20
KRT38
LAMB2
LMNA
LTBP3
MET
MRFAP1L1
PDGFRB
PIK3CD
RINT1
SEPTIN2
SHC1
SOCS1
SOCS6
SOCS7
SOS1
STAB1
STAT3
SYK
TEC
TGFBR1
TGFBR2
TRIM23
WASF3
YWHAB
Entrez ID
940
5296
HPRD ID
01727
04404
Ensembl ID
ENSG00000178562
ENSG00000105647
Uniprot IDs
B4E0L1
P10747
O00459
PDB IDs
1YJD
3WA4
5AUL
5GJH
5GJI
6O8D
2KT1
2XS6
3MTT
3O5Z
6OX7
6U28
Enriched GO Terms of Interacting Partners
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