CXCL8 and POMGNT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CXCL8	POMGNT1
Description		C-X-C motif chemokine ligand 8	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Membrane Integral Component Of Membrane Integral Component Of Golgi Membrane
	Molecular Function	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	Protein Binding Acetylglucosaminyltransferase Activity Manganese Ion Binding Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Positive Regulation Of Cellular Biosynthetic Process Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Regulation Of Cell Cycle Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell	Protein O-linked Glycosylation O-glycan Processing
Pathways		Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 O-linked glycosylation
Drugs		ABT-510 MDX-018 Rivanicline Tapinarof
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)	Body mass index ( 26426971)
Interacting Genes		22 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598	12 interacting genes: BRCA1 CD74 CISD2 CXCL8 CXorf66 ERGIC3 LNX1 MBD1 RXYLT1 SOX6 TMEM237 ZBTB18
Entrez ID		3576	55624
HPRD ID		00909	09493
Ensembl ID		ENSG00000169429	ENSG00000085998
Uniprot IDs		A0A024RDA5 P10145	B7Z7F2 B7Z7Q4 Q8WZA1
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM	5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC
Enriched GO Terms of Interacting Partners?
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