SHROOM2 and ACE2

Data Source:
BioGRID (pull down)

		SHROOM2	ACE2
Description		shroom family member 2	angiotensin converting enzyme 2
Image
GO Annotations	Cellular Component	Cytoskeleton Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Apical Plasma Membrane Cortical Actin Cytoskeleton Apical Junction Complex Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Beta-catenin Binding Ligand-gated Sodium Channel Activity Actin Filament Binding	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Lens Morphogenesis In Camera-type Eye Actin Filament Organization Brain Development Eye Pigment Granule Organization Cell Migration Establishment Of Melanosome Localization Melanosome Organization Sodium Ion Transmembrane Transport Camera-type Eye Development Cellular Pigment Accumulation Ear Development Apical Protein Localization Camera-type Eye Morphogenesis Actin Filament Bundle Assembly	Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Tryptophan Transport Regulation Of Vasoconstriction Regulation Of Transmembrane Transporter Activity Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Positive Regulation Of Cardiac Muscle Contraction Blood Vessel Diameter Maintenance Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry
Drugs			Chloroquine Hydroxychloroquine SPP1148 N-(2-Aminoethyl)-1-aziridineethanamine
Diseases
GWAS		Colorectal cancer ( 22634755) Prostate cancer ( 23535732)
Interacting Genes		3 interacting genes: ACE2 RPS6KA1 YWHAG	25 interacting genes: AGT CALM1 CDSN DEFA5 DLEU2 GHRL MAST1 MAST2 NTS PARD3 PDZK1 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SLC6A19 SLC9A3R1 SLC9A3R2 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D
Entrez ID		357	59272
HPRD ID		02113	02274
Ensembl ID		ENSG00000146950	ENSG00000130234
Uniprot IDs		B7Z682 F5H3B6 Q13796 Q68DU3	Q9BYF1
PDB IDs		5F4Y 5F5P	1R42 1R4L 1XJP 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DF4 7DMU 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F
Enriched GO Terms of Interacting Partners?
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