IL5RA and UNC119

Number of citations of the paper that reports this interaction (PubMedID 12496276)
24

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		IL5RA	UNC119
Description		interleukin 5 receptor subunit alpha	unc-119 lipid binding chaperone
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Spindle Pole Centrosome Cytosol Intercellular Bridge Synapse Spindle Midzone
	Molecular Function	Cytokine Receptor Activity Interleukin-5 Receptor Activity Protein Binding Cytokine Binding	Protein Binding Lipid Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation	Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Benralizumab
Diseases
GWAS		Asthma (childhood onset) ( 22560479) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Oleic acid (18:1n-9) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		7 interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119	103 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24
Entrez ID		3568	9094
HPRD ID		00998	04927
Ensembl ID		ENSG00000091181	ENSG00000109103
Uniprot IDs		A0A024R2E8 Q01344 Q8NHV7	K7EN86 Q13432
PDB IDs		1OBX 1OBZ 3QT2 3VA2 6H41	3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A
Enriched GO Terms of Interacting Partners?
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