IGFBP6 and PLEKHA7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IGFBP6	PLEKHA7
Description		insulin like growth factor binding protein 6	pleckstrin homology domain containing A7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex	Nucleoplasm Centrosome Cytosol Zonula Adherens Cell Junction Pore Complex Extracellular Exosome
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding	Protein Binding Delta-catenin Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	Cell-cell Adhesion Mediated By Cadherin Zonula Adherens Maintenance Pore Complex Assembly Epithelial Cell-cell Adhesion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Blood pressure ( 21909110) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Coronary artery disease ( 29212778) Diastolic blood pressure ( 19430479 27841878 28739976 27618452) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Glaucoma (primary angle closure) ( 22922875 27064256) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29617998 29785010 31959993 30054594) Macular thickness ( 30535121) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Microalbuminuria in type 1 diabetes ( 31537649) Systolic blood pressure ( 19430479 27841878 28739976 27618452 30578418) Systolic blood pressure change trajectory ( 27980656) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		40 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DDX10 EFEMP1 EFEMP2 ENKD1 EPDR1 ERBB3 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587	21 interacting genes: ADAM9 B9D2 CCHCR1 CCNDBP1 FAM228A GRB2 HOMEZ HSF2BP IGFBP6 IGFL2 LZTS1 NEK6 PIBF1 PICK1 PPL RDH12 RHOH STMN3 TRAF4 TSGA10 ZMAT5
Entrez ID		3489	144100
HPRD ID		00902	15142
Ensembl ID		ENSG00000167779	ENSG00000166689
Uniprot IDs		P24592	E9PKC0 Q6IQ23
PDB IDs		1RMJ
Enriched GO Terms of Interacting Partners?
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