PLEKHA7 and RDH12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLEKHA7	RDH12
Description		pleckstrin homology domain containing A7	retinol dehydrogenase 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Zonula Adherens Cell Junction Pore Complex Extracellular Exosome	Photoreceptor Inner Segment Endoplasmic Reticulum Membrane Photoreceptor Inner Segment Membrane
	Molecular Function	Protein Binding Delta-catenin Binding	NAD-retinol Dehydrogenase Activity Protein Binding NADP-retinol Dehydrogenase Activity 11-cis-retinol Dehydrogenase Activity
	Biological Process	Cell-cell Adhesion Mediated By Cadherin Zonula Adherens Maintenance Pore Complex Assembly Epithelial Cell-cell Adhesion	Retinoid Metabolic Process Visual Perception Retinol Metabolic Process Photoreceptor Cell Maintenance Cellular Detoxification Of Aldehyde
Pathways			Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)
Drugs			Vitamin A
Diseases
GWAS		Blood pressure ( 21909110) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Coronary artery disease ( 29212778) Diastolic blood pressure ( 19430479 27841878 28739976 27618452) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Glaucoma (primary angle closure) ( 22922875 27064256) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29617998 29785010 31959993 30054594) Macular thickness ( 30535121) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Microalbuminuria in type 1 diabetes ( 31537649) Systolic blood pressure ( 19430479 27841878 28739976 27618452 30578418) Systolic blood pressure change trajectory ( 27980656) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		21 interacting genes: ADAM9 B9D2 CCHCR1 CCNDBP1 FAM228A GRB2 HOMEZ HSF2BP IGFBP6 IGFL2 LZTS1 NEK6 PIBF1 PICK1 PPL RDH12 RHOH STMN3 TRAF4 TSGA10 ZMAT5	6 interacting genes: ADCY2 ANXA8L1 BUB1 MAP1LC3A PLEKHA7 RBPMS
Entrez ID		144100	145226
HPRD ID		15142	10585
Ensembl ID		ENSG00000166689	ENSG00000139988
Uniprot IDs		E9PKC0 Q6IQ23	A0A0S2Z613 Q96NR8
PDB IDs
Enriched GO Terms of Interacting Partners?
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