KCNT2 and DENND1B

		KCNT2	DENND1B
Description		potassium sodium-activated channel subfamily T member 2	DENN domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytosol Nuclear Speck Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Intracellular Sodium Activated Potassium Channel Activity ATP Binding Outward Rectifier Potassium Channel Activity Chloride-activated Potassium Channel Activity	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Potassium Ion Export Across Plasma Membrane	Endocytosis Protein Transport Endocytic Recycling Positive Regulation Of GTPase Activity Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Idiopathic dilated cardiomyopathy ( 29495422) Lung cancer in ever smokers ( 28604730) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 ( 26634245) Takayasu arteritis ( 25604533) Total ventricular volume ( 21116278) Waist-hip index ( 34021172)	Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		1 interacting genes: DENND1B	5 interacting genes: ATP6V1G3 GLRX2 KCNT2 LNX1 ZBTB41
Entrez ID		343450	163486
HPRD ID		11584	13303
Ensembl ID		ENSG00000162687	ENSG00000213047
Uniprot IDs		A0A3B3IRL4 A9LNM6 Q6UVM3	A0A024R987 Q6P3S1
PDB IDs			3TW8
Enriched GO Terms of Interacting Partners?
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