DENND1B and ATP6V1G3

		DENND1B	ATP6V1G3
Description		DENN domain containing 1B	ATPase H+ transporting V1 subunit G3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Nuclear Speck Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle	Cytosol Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Phosphatidylinositol Phosphate Binding	Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Endocytosis Protein Transport Endocytic Recycling Positive Regulation Of GTPase Activity Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production	Proton Transmembrane Transport
Pathways		RAB GEFs exchange GTP for GDP on RABs	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)	Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) ( 23648065) Asthma ( 31959851) Body mass index ( 28552196) General risk tolerance (MTAG) ( 30643258) Mean corpuscular hemoglobin ( 29403010 20139978) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Multiple sclerosis ( 31604244) Pulse pressure ( 33230300) Red blood cell count ( 29403010)
Interacting Genes		5 interacting genes: ATP6V1G3 GLRX2 KCNT2 LNX1 ZBTB41	3 interacting genes: DENND1B LMAN2L OTX2
Entrez ID		163486	127124
HPRD ID		13303	16526
Ensembl ID		ENSG00000213047	ENSG00000151418
Uniprot IDs		A0A024R987 Q6P3S1	Q96LB4
PDB IDs		3TW8
Enriched GO Terms of Interacting Partners?
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