KLHL38 and FTO

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KLHL38	FTO
Description		kelch like family member 38	FTO alpha-ketoglutarate dependent dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Ferrous Iron Binding Transferase Activity Oxidative RNA Demethylase Activity Oxidative DNA Demethylase Activity DNA-N1-methyladenine Dioxygenase Activity MRNA N6-methyladenosine Dioxygenase Activity TRNA Demethylase Activity
	Biological Process		Temperature Homeostasis DNA Dealkylation Involved In DNA Repair Regulation Of Lipid Storage Oxidative Single-stranded DNA Demethylation Oxidative Single-stranded RNA Demethylation Regulation Of Multicellular Organism Growth RNA Repair Regulation Of Respiratory System Process Adipose Tissue Development MRNA Destabilization Regulation Of White Fat Cell Proliferation Oxidative Demethylation DNA Demethylation Regulation Of Brown Fat Cell Differentiation
Pathways			Reversal of alkylation damage by DNA dioxygenases
Drugs			Artenimol
Diseases
GWAS		Atrial fibrillation ( 29892015) Carotid intima media thickness (mean) ( 31801372) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Heel bone mineral density ( 30598549) PR interval ( 32439900) QRS duration ( 30012220) Systolic blood pressure ( 30578418)	Adiposity ( 21706003) Adolescent idiopathic scoliosis ( 31417091) Adult body size ( 32376654) Age at adiposity rebound ( 31840077) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Beef consumption ( 32066663) Biomedical quantitative traits ( 19396169) Blood glucose levels ( 31928498) Blood urea nitrogen levels ( 31152163 29403010) BMI (adjusted for smoking behaviour) ( 28443625) BMI at 7 years old ( 31575865) BMI at 8 years old ( 31575865) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body fat percentage ( 26833246 28270201 31453325) Body fat percentage variance ( 31453325) Body mass in chronic obstructive pulmonary disease ( 21037115) Body mass index ( 28552196 31513605 29381148 31888951 30045251 24064335 22982992 23563607 26426971 19079260 19079261 26961502 24348519 23669352 24861553 28270201 18454148 31453325 28892062 25673413 20935630 23583978 28448500 17434869 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 29059683 23535729 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast size ( 27182965) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from tea ( 33287642) Childhood body mass index ( 33045005 26604143) Chromosomal aberration frequency (chromosome type) ( 31586183) Chronotype ( 30696823) circulating leptin levels ( 32917775 26833098) Coffee consumption ( 31046077) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Dietary macronutrient intake ( 23636237 29988085) End-stage kidney disease ( 31178898) Eyebrow thickness ( 26926045) Facial morphology ( 31763980) Fasting insulin ( 33402679) Fish- and plant-related diet ( 32066663) Glycated hemoglobin levels ( 28898252) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) Heel bone mineral density ( 30598549 28869591) Height adjusted BMI ( 25044758) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference ( 28552196 31453325 25673412) Hip circumference variance ( 31453325) Intake of total sugars ( 31005972) LDL cholesterol levels ( 32203549) Lean body mass ( 28552196 28724990) Liver enzyme levels (alanine transaminase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) in asthma ( 32989782) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Melanoma ( 28212542 23455637) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 22399527 31589552) Morning person ( 30696823) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-oily fish consumption ( 32066663) Number of sexual partners ( 30643258) Obese vs. thin ( 30677029) Obesity ( 23563607 19151714 21544081 21552555) Obesity (early onset extreme) ( 20421936 23563609 18159244) Obesity (extreme) ( 30677029 31852448 19553259) Obesity-related traits ( 17658951) Obstructive sleep apnea ( 33243845) Oily fish consumption ( 32066663) Opioid dependence (time to event) ( 34124712) Osteoarthritis ( 22763110) Pork consumption ( 32066663) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Pure non-grapefruit juice consumption ( 31046077) Red cell distribution width ( 28957414) Red vs. brown/black hair color ( 30531825) Relative sugar intake ( 32393786) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Sasang constitutional medicine type (So-Eum) ( 25888059) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Sex hormone-binding globulin levels ( 22675492) Sleep duration (long sleep) ( 30846698) Strenuous sports or other exercises ( 29899525) Subcutaneous adipose tissue ( 22589738 27918534) Subscapular skin fold thickness ( 31513605) Sugar-sweetened beverage consumption ( 31046077) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 31928498) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924) Triglyceride levels ( 28334899 32902719) Triglycerides ( 24097068 30275531) Trunk fat mass ( 28552196) Type 2 diabetes ( 22885922 18372903 24509480 30054458 22693455 26961502 30297969 17554300 26818947 32499647 20581827 30718926 17463248 17463249 28869590 19056611 23209189) Type 2 diabetes nephropathy ( 30566433) Type 2 diabetes nephropathy including microalbuminuria ( 30566433) Urate levels ( 31578528) Urinary sodium excretion ( 31409800) Urolithiasis ( 30975718) Waist circumference ( 28552196 19557197 31453325 31928498 25673412) Waist circumference variance ( 31453325) Waist-hip ratio ( 28552196 25673412) Walking pace ( 33128006) Weight ( 28552196 19079260)
Interacting Genes		88 interacting genes: ADAMTSL4 ADRA2C AGR2 ASB12 BHLHB9 BLZF1 C11orf1 CCDC33 CERCAM CFP CTAG1A CTAG1B CYSRT1 DMAC2L ECM1 FTO GOLGA6A GSC2 HDHD3 IKZF3 KLHL20 KRT27 KRT31 KRT34 KRT35 KRT38 KRT39 KRT40 KRT85 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP13-1 KRTAP13-2 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-11 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LHX3 LHX4 MAGEA6 MDFI MEOX2 MGAT5B MKRN3 MORN3 NBPF19 NOTCH2NLA OIP5 PAX5 PBX4 PFDN5 PLSCR4 POF1B POU2AF1 RGS20 RSPO4 SLC15A2 SPRY4 TACC3 TADA2A TCF4 TEKT1 TEKT5 TENT5B TEPSIN TIMM10B TRAF1 TRIB3 TRIM42 TRIM54 TRIM69 TXNDC11 UBE3A USHBP1 WFDC5 WWOX YPEL3 ZNF341	21 interacting genes: ANKRD11 C1orf109 CCDC57 CLP1 CXCR4 DTX2 EFEMP2 GNG13 GPANK1 IL16 KLHL38 MAD2L2 MORN3 NXF1 OGT PRDM6 SHC3 TNPO2 TTC19 USP20 ZNF77
Entrez ID		340359	79068
HPRD ID		19276	19057
Ensembl ID		ENSG00000175946	ENSG00000140718
Uniprot IDs		Q2WGJ6	A0A1B0GTC5 B3KU60 Q99770 Q9C0B1
PDB IDs			3LFM 4CXW 4CXX 4CXY 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7 4QHO 4QKN 4ZS2 4ZS3 5DAB 5F8P 5ZMD 6AEJ 6AK4 6AKW
Enriched GO Terms of Interacting Partners?
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