ESPNL and LDLRAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ESPNL	LDLRAP1
Description		espin like	low density lipoprotein receptor adaptor protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Stereocilium Tip	Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Recycling Endosome
	Molecular Function	Protein Binding Actin Filament Binding	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Sensory Perception Of Sound Actin Filament Bundle Assembly	Receptor-mediated Endocytosis Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance
Drugs
Diseases
GWAS			Cholesterol, total ( 24097068 25961943 20686565) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		3 interacting genes: LDLRAP1 PFDN5 SERTAD2	18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 STN1 TFAP2A
Entrez ID		339768	26119
HPRD ID		14170	05765
Ensembl ID		ENSG00000144488	ENSG00000157978
Uniprot IDs		B3KXY4 Q6ZVH7	B3KR97 Q5SW96
PDB IDs			2G30
Enriched GO Terms of Interacting Partners?
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