LDLRAP1 and PSD4

Number of citations of the paper that reports this interaction (PubMedID 25910212)
170

Data Source:
BioGRID (two hybrid, two hybrid)

		LDLRAP1	PSD4
Description		low density lipoprotein receptor adaptor protein 1	pleckstrin and Sec7 domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Recycling Endosome	Membrane Cleavage Furrow Ruffle Membrane
	Molecular Function	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding	Guanyl-nucleotide Exchange Factor Activity Phospholipid Binding
	Biological Process	Receptor-mediated Endocytosis Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068 25961943 20686565) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)	Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Diastolic blood pressure ( 28548082) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lymphocyte counts ( 32888494) Red blood cell count ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 STN1 TFAP2A	2 interacting genes: LDLRAP1 USP9X
Entrez ID		26119	23550
HPRD ID		05765	15191
Ensembl ID		ENSG00000157978	ENSG00000125637
Uniprot IDs		B3KR97 Q5SW96	Q8NDX1
PDB IDs		2G30
Enriched GO Terms of Interacting Partners?
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