HTR4 and TSPAN7

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		HTR4	TSPAN7
Description		5-hydroxytryptamine receptor 4	tetraspanin 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Synapse	Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Appetite
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
Drugs		Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)	White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7	23 interacting genes: ADRB2 BBS1 BUD31 CACNA1A CCR2 CCR9 CHRM2 CHRM4 CREB3 DRD2 FAM209A FYTTD1 GNRHR GPR152 GPR35 HTR4 LHFPL5 LMNA LTB4R2 MEOX2 OXTR RPGR SMO
Entrez ID		3360	7102
HPRD ID		09074	02107
Ensembl ID		ENSG00000164270	ENSG00000156298
Uniprot IDs		A0A2D3FAF9 Q13639	P41732
PDB IDs		5EM9
Enriched GO Terms of Interacting Partners?
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