HTR4 and TMEFF2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		HTR4	TMEFF2
Description		5-hydroxytryptamine receptor 4	transmembrane protein with EGF like and two follistatin like domains 2
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Synapse	Extracellular Region Basement Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding	Molecular_function Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Appetite	Animal Organ Morphogenesis Tissue Development Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Wound Healing, Spreading Of Cells Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Stress Fiber Assembly
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)	Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diabetes (incident) ( 17903298) Schizophrenia ( 33169155) Sudden cardiac arrest ( 21658281)
Interacting Genes		18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7	12 interacting genes: DNAH7 DRD2 HSF2BP HTR4 NBPF19 NOTCH2NLA RIC3 STAT4 TMEM237 TRHR UBIAD1 ZDHHC15
Entrez ID		3360	23671
HPRD ID		09074	05760
Ensembl ID		ENSG00000164270	ENSG00000144339
Uniprot IDs		A0A2D3FAF9 Q13639	Q9UIK5
PDB IDs		5EM9	2FMW
Enriched GO Terms of Interacting Partners?
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