HTR2B and ABCA3

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		HTR2B	ABCA3
Description		5-hydroxytryptamine receptor 2B	ATP binding cassette subfamily A member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex	Extracellular Space Lysosomal Membrane Late Endosome Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Multivesicular Body Membrane Lamellar Body Intracellular Membrane-bounded Organelle Alveolar Lamellar Body Lamellar Body Membrane Alveolar Lamellar Body Membrane
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding	Lipid Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Transfer Activity Phosphatidylcholine Flippase Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Behavior Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Embryonic Morphogenesis Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus G Protein-coupled Serotonin Receptor Signaling Pathway	Xenobiotic Transmembrane Transport Lipid Transport Response To Xenobiotic Stimulus Positive Regulation Of Cholesterol Efflux Phospholipid Transport Lung Development Positive Regulation Of Protein Homooligomerization Lipid Translocation Xenobiotic Transport Surfactant Homeostasis Cellular Protein Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Xenobiotic Export Regulation Of Lipid Biosynthetic Process Response To Glucocorticoid Phospholipid Homeostasis Organelle Assembly Intermembrane Lipid Transfer Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Phospholipid Efflux Positive Regulation Of Phospholipid Transport
Pathways		Serotonin receptors G alpha (q) signalling events	ABC transporters in lipid homeostasis Defective ABCA3 causes SMDP3 Surfactant metabolism Defective ABCA3 causes SMDP3
Drugs		Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine
Diseases
GWAS		Proportion of activated microglia (midfrontal cortex) ( 30679421) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Birth weight ( 31043758) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Trunk fat mass ( 28552196)
Interacting Genes		27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1	1 interacting genes: HTR2B
Entrez ID		3357	21
HPRD ID		03077	03369
Ensembl ID		ENSG00000135914	ENSG00000167972
Uniprot IDs		P41595	Q4LE27 Q99758
PDB IDs		4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0
Enriched GO Terms of Interacting Partners?
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