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HTR2A and SUGT1
HTR2A
SUGT1
Description
5-hydroxytryptamine receptor 2A
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Axon
Dendrite
Cytoplasmic Vesicle
Neuronal Cell Body
Dendritic Shaft
Cell Body Fiber
G Protein-coupled Serotonin Receptor Complex
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Ubiquitin Ligase Complex
Kinetochore
Nucleus
Cytosol
Protein-containing Complex
Molecular Function
Gq/11-coupled Serotonin Receptor Activity
Virus Receptor Activity
G Protein-coupled Serotonin Receptor Activity
Protein Binding
Neurotransmitter Receptor Activity
Identical Protein Binding
Protein-containing Complex Binding
Serotonin Binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
Protein Binding
Chaperone Binding
Biological Process
Temperature Homeostasis
Cellular Calcium Ion Homeostasis
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Phospholipase C-activating Serotonin Receptor Signaling Pathway
Serotonin Receptor Signaling Pathway
Chemical Synaptic Transmission
Aging
Memory
Cell Death
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Positive Regulation Of Phosphatidylinositol Biosynthetic Process
Regulation Of Dopamine Secretion
Phosphatidylinositol 3-kinase Signaling
Artery Smooth Muscle Contraction
Urinary Bladder Smooth Muscle Contraction
Sleep
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of MAP Kinase Activity
Protein Localization To Cytoskeleton
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Glycolytic Process
Positive Regulation Of Vasoconstriction
Viral Entry Into Host Cell
Behavioral Response To Cocaine
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Synaptic Transmission, Glutamatergic
Positive Regulation Of ERK1 And ERK2 Cascade
G Protein-coupled Serotonin Receptor Signaling Pathway
Regulation Of Synaptic Vesicle Exocytosis
Mitotic Cell Cycle
Regulation Of Protein Stability
Protein Stabilization
Pathways
Serotonin receptors
G alpha (q) signalling events
The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
Drugs
Ziprasidone
Methysergide
Cabergoline
Zolmitriptan
Amitriptyline
Olanzapine
Clozapine
Mirtazapine
Loxapine
Remoxipride
Promazine
Cyproheptadine
Imipramine
Chlorpromazine
Chlorpromazine
Haloperidol
Nortriptyline
Amoxapine
Lamotrigine
Fenfluramine
Lisuride
Cisapride
Fluphenazine
Trazodone
Thioridazine
Ergotamine
Apomorphine
Paroxetine
Paroxetine
Trimipramine
Risperidone
Epinastine
Propiomazine
Minaprine
Donepezil
Flupentixol
Cyclobenzaprine
Mesoridazine
Maprotiline
Ergoloid mesylate
Tegaserod
Doxepin
Nefazodone
Desipramine
Escitalopram
Pergolide
Bromocriptine
Ketamine
Quetiapine
Aripiprazole
Chlorprothixene
Chlorprothixene
Clomipramine
Paliperidone
Yohimbine
Methotrimeprazine
MMDA
Midomafetamine
Dimethyltryptamine
4-Bromo-2,5-dimethoxyphenethylamine
Acepromazine
Molindone
Pipotiazine
Thioproperazine
Thiothixene
Zuclopenthixol
Aniracetam
Fluspirilene
Flibanserin
Iloperidone
HY10275
APD791
Pimavanserin
Epicept NP-1
BL-1020
Cariprazine
Lumateperone
YKP-1358
Sertindole
Mianserin
Pizotifen
Asenapine
Ocaperidone
Amisulpride
Dotarizine
Deramciclane
Esmirtazapine
Cinitapride
Lurasidone
Serotonin
Perospirone
Amperozide
Butriptyline
Cannabidiol
Brexpiprazole
Dosulepin
Etoperidone
Lorpiprazole
Blonanserin
Zotepine
Pipamperone
Setiptiline
Dihydroergocornine
Gilteritinib
Sarpogrelate
Eplivanserin
Ketanserin
Nelotanserin
Ritanserin
Tiapride
Dihydroergocristine
2,5-Dimethoxy-4-ethylthioamphetamine
N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine
Medical Cannabis
5-methoxy-N,N-dimethyltryptamine
Nabiximols
Aripiprazole lauroxil
Diseases
GWAS
Blood protein levels (
28240269
)
Cardiac hypertrophy (
21348951
)
Parkinson disease and lewy body pathology (
25663231
)
Serum 25-Hydroxyvitamin D levels (
29325163
)
Sjögren's syndrome (
28076899
)
Subcutaneous adipose tissue (
22589738
)
Interacting Genes
25 interacting genes:
ANKS1B
ARF1
ARF6
CTSG
DACH1
DIRAS3
DLG1
DLG4
EIF3F
GLUL
GNA11
GNAI1
GNAQ
JAK2
MAP1A
MRPL28
NDUFB10
NME3
NTRK3
PCDH9
PON2
PPP5C
RFXAP
RPS6KA3
SUGT1
18 interacting genes:
BUB3
CSNK2A1
DSN1
HSP90AA1
HSPA4
HTR2A
MIS12
NR4A1
NSL1
PAXIP1
PHLPP1
PLK1
PMF1
PTGER4
S100A6
S100B
S100P
SKP1
Entrez ID
3356
10910
HPRD ID
01638
09160
Ensembl ID
ENSG00000102468
ENSG00000165416
Uniprot IDs
P28223
A8K7W3
B4DYC6
Q9Y2Z0
PDB IDs
6A93
6A94
6WGT
6WH4
6WHA
1RL1
Enriched GO Terms of Interacting Partners
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