SUGT1 and PHLPP1

Number of citations of the paper that reports this interaction (PubMedID 28696259)
2

Data Source:
BioGRID (enzymatic study)

		SUGT1	PHLPP1
Description		SGT1 homolog, MIS12 kinetochore complex assembly cochaperone	PH domain and leucine rich repeat protein phosphatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Cytosol Protein-containing Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Chaperone Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Protein Stability Protein Stabilization	Regulation Of T Cell Anergy Protein Dephosphorylation Apoptotic Process Signal Transduction Entrainment Of Circadian Clock Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of Protein Kinase B Signaling Regulation Of P38MAPK Cascade
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Negative regulation of the PI3K/AKT network
Drugs
Diseases
GWAS			Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Hip circumference adjusted for BMI ( 28552196) Plateletcrit ( 32888494)
Interacting Genes		18 interacting genes: BUB3 CSNK2A1 DSN1 HSP90AA1 HSPA4 HTR2A MIS12 NR4A1 NSL1 PAXIP1 PHLPP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1	8 interacting genes: BRAP CSNK1A1 GSK3B SERPINB7 SLC9A3R1 SUGT1 WDR48 ZCCHC2
Entrez ID		10910	23239
HPRD ID		09160	15145
Ensembl ID		ENSG00000165416	ENSG00000081913
Uniprot IDs		A8K7W3 B4DYC6 Q9Y2Z0	O60346
PDB IDs		1RL1
Enriched GO Terms of Interacting Partners?
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