BIRC5 and FBXL7

Number of citations of the paper that reports this interaction (PubMedID 28218735)
29

Data Source:
BioGRID (enzymatic study)

		BIRC5	FBXL7
Description		baculoviral IAP repeat containing 5	F-box and leucine rich repeat protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex	Ubiquitin Ligase Complex Centrosome Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding Small GTPase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding	Protein Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Reserpine Berberine LY2181308
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)	Adverse response to drug ( 30420678) Alzheimer's disease (late onset) ( 26339675) Asthma (corticosteroid response) ( 24486069) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (feminism/equality) ( 22566634) Haemorrhoidal disease ( 33888516) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Response to fenofibrate (total cholesterol levels) ( 27002377) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral fat ( 22589738)
Interacting Genes		34 interacting genes: AANAT AKAP6 AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 CSNK1D DIABLO EVI5 FASN FBXL7 GCGR H3-4 H3C14 HSP90AA1 INCENP KCNJ6 NNMT OGT RAN RASA1 SSH2 TLE3 XIAP XPO1	6 interacting genes: APP BIRC5 FBXL18 FCHO1 IMPDH2 TBC1D5
Entrez ID		332	23194
HPRD ID		04520	05740
Ensembl ID		ENSG00000089685	ENSG00000183580
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	Q9UJT9
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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