BIRC2 and IKBKE

Number of citations of the paper that reports this interaction (PubMedID 23453969)
29

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		BIRC2	IKBKE
Description		baculoviral IAP repeat containing 2	inhibitor of nuclear factor kappa B kinase subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	XY Body Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Mitochondrial Membrane
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin Binding Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Ubiquitin Protein Ligase Activity FBXO Family Protein Binding	Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Polyubiquitination Response To Hypoxia Placenta Development Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Positive Regulation Of Lipid Storage Peptidyl-serine Phosphorylation Response To Type I Interferon Response To Interferon-beta NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly MRNA Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Type I Interferon-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Virus
Pathways		Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs			Fostamatinib
Diseases
GWAS		Prostate cancer ( 23535732)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966 33272962)
Interacting Genes		76 interacting genes: ABHD17A BIRC5 BLK BMX BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 CBLC CD40 CDC42 CSE1L DIABLO DZIP3 E2F1 EAF2 EIF4E EXOSC5 FBXO7 FDX1 GAS1 GCC1 GFAP GLMN GSPT1 HSP90B1 HTRA2 IGF2BP1 IKBKE IKBKG JUP KDM1A LNX1 LTBR MAD1L1 MAGEA11 MAP3K2 MAP3K3 NMB NXF1 OTUB1 PACS2 PCSK9 PFN2 PPM1K RAC1 RAF1 RFC5 RHOA RIPK2 RIPK3 RIPK4 RNF181 RUNX1T1 TCAF1 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 TUFT1 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2N UBE2Q2 UBE2S UBE2V1 UBE2W	26 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CSF2 CYLD DAXX DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP MUC1 NFKBIA PTGFR RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP
Entrez ID		329	9641
HPRD ID		03419	05442
Ensembl ID		ENSG00000110330	ENSG00000263528
Uniprot IDs		Q13490	A0A075B7B4 Q14164
PDB IDs		1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7 5M6N 6EXW 6HPR 6W74 6W7O 6W8I
Enriched GO Terms of Interacting Partners?
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