HRH2 and SLIT3

		HRH2	SLIT3
Description		histamine receptor H2	slit guidance ligand 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Extracellular Space Mitochondrion
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity	Calcium Ion Binding Heparin Binding Roundabout Binding
	Biological Process	Gastric Acid Secretion Immune Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Positive Regulation Of Vasoconstriction G Protein-coupled Serotonin Receptor Signaling Pathway	Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Axon Guidance Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways		Histamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs		Betazole Amitriptyline Loxapine Cimetidine Nizatidine Epinastine Olopatadine Tolazoline Ranitidine Famotidine Methantheline Azelastine Promethazine Doxepin Aripiprazole HZT-501 Histamine Asenapine Metiamide Roxatidine acetate
Diseases
GWAS		Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Mosquito bite size ( 28199695) Night sleep phenotypes ( 27126917)	Atrial fibrillation ( 30061737) Bipolar disorder x sex interaction ( 34099189) Body mass index ( 31217584) Circulating leptin levels in high cardiovascular risk ( 31766143) Circulating leptin levels x sex interaction in high cardiovascular risk ( 31766143) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Gut microbiota (functional units) ( 27694959) Hallux valgus ( 32131869) Height ( 28552196 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory skin disease ( 25574825) Menarche (age at onset) ( 25231870) Non-word reading ( 30741946) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Treatment resistant depression ( 30468137)
Interacting Genes		2 interacting genes: GPRASP2 SLIT3	11 interacting genes: CAPN1 CASP9 HRH2 IGSF8 KHDRBS3 MAML1 MAPK9 MGAT4B ROBO2 RXRB SQSTM1
Entrez ID		3274	6586
HPRD ID		00816	04775
Ensembl ID		ENSG00000113749	ENSG00000184347
Uniprot IDs		A0A1B0GTK7 P25021	O75094
PDB IDs
Enriched GO Terms of Interacting Partners?
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