MMAB and MTRR

Number of citations of the paper that reports this interaction (PubMedID 15347655)
27

Data Source:
HPRD (in vitro)

		MMAB	MTRR
Description		metabolism of cobalamin associated B	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
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GO Annotations	Cellular Component	Mitochondrial Matrix	Nucleoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding ATP Binding Cob(I)yrinic Acid A,c-diamide Adenosyltransferase Activity Cobalamin Binding	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase Activity Flavin Adenine Dinucleotide Binding NADPH Binding FAD Binding
	Biological Process	Cobalamin Metabolic Process	DNA Methylation Methionine Biosynthetic Process S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Negative Regulation Of Cystathionine Beta-synthase Activity
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMAB causes methylmalonic aciduria type cblB	Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Drugs			Cyanocobalamin Methionine
Diseases
GWAS		Age-related nuclear cataracts ( 33311586 24951543) Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 18193043 20864672 19060906 25961943 20686565) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Monocyte percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Polymyositis ( 26362759) Pork consumption ( 32066663) Red cell distribution width ( 32888494)	Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Interacting Genes		2 interacting genes: CBY2 MTRR	3 interacting genes: GFER GMCL1 MMAB
Entrez ID		326625	4552
HPRD ID		07398	03979
Ensembl ID		ENSG00000139428	ENSG00000124275
Uniprot IDs		Q96EY8	Q9UBK8
PDB IDs		2IDX 6D5K 6D5X	2QTL 2QTZ
Enriched GO Terms of Interacting Partners?
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