HNRNPK and ITSN2

Number of citations of the paper that reports this interaction (PubMedID 22558309)
25

Data Source:
BioGRID (two hybrid)

		HNRNPK	ITSN2
Description		heterogeneous nuclear ribonucleoprotein K	intersectin 2
Image
GO Annotations	Cellular Component	Chromatin Podosome Nucleus Nucleoplasm Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome	Cytoplasm Centrosome Plasma Membrane Clathrin-coated Pit Presynaptic Membrane Extracellular Exosome Intracellular Vesicle Presynapse
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II RNA Processing Signal Transduction Regulation Of Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Low-density Lipoprotein Receptor Activity	Endocytosis Endosomal Transport Cell Differentiation Regulation Of Catalytic Activity Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Lymphocyte counts ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglyceride levels ( 32203549)	Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067) Total cholesterol levels ( 33339817)
Interacting Genes		222 interacting genes: - ABI1 ABI2 ADRB2 ANKRD28 APBB1 APOBEC1 APOBEC3C AQP5 AURKA BTRC C6orf223 C6orf226 CBLB CCAR1 CCDC187 CCDC33 CDKN1A CEBPB CIRBP CMTM5 CNNM3 CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 DUX4 EIF3F ELAVL1 ETNK2 FBXL18 FBXO7 FBXW7 FOXD4L1 FOXD4L3 FYN GFI1B GRAP2 GRB2 GZMA GZMK H3-4 HBZ HCK HMGB1 HNRNPA0 HNRNPL HNRNPLL IRGC ITK ITSN2 KCTD8 KHDRBS1 KHDRBS2 KHDRBS3 KLF1 LYN MAP2K2 MAPK10 MARK4 MATR3 MDM2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MISP MRPL9 MYPOP NCK2 NEDD4 NOTO NPDC1 OGT PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PGAP6 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A PRR3 QKI RALY RAMAC RASAL3 RASD1 RBFOX2 RBM10 RBM14 RBM3 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 RNA18SN5 RNA28SN5 RNF4 RPH3AL RTP5 SAFB SF1 SHANK3 SMAD3 SNRPA SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TCF23 TERF2IP TH TLE5 TYK2 U2AF1 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 YWHAQ ZFC3H1 ZNF385C ZNF408 ZNF526 ZNF575 ZNF688 ZNF792 ZNRF2P1	77 interacting genes: AGT AHDC1 AMPH ANKRD17 B4GALT2 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RRM2 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		3190	50618
HPRD ID		02834	09193
Ensembl ID		ENSG00000165119	ENSG00000198399
Uniprot IDs		B4DUQ1 P61978	A6H8W8 Q9NZM3
PDB IDs		1J5K 1KHM 1ZZI 1ZZJ 1ZZK	1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?
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