ITSN2 and CPSF6

Number of citations of the paper that reports this interaction (PubMedID 22558309)
25

Data Source:
BioGRID (two hybrid)

		ITSN2	CPSF6
Description		intersectin 2	cleavage and polyadenylation specific factor 6
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Plasma Membrane Clathrin-coated Pit Presynaptic Membrane Extracellular Exosome Intracellular Vesicle Presynapse	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane Nuclear Speck Interchromatin Granule Paraspeckles Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity	RNA Binding MRNA Binding Protein Binding Ribosomal Large Subunit Binding Exon-exon Junction Complex Binding
	Biological Process	Endocytosis Endosomal Transport Cell Differentiation Regulation Of Catalytic Activity Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension	MRNA Processing Positive Regulation Of RNA Export From Nucleus Protein Tetramerization Protein Heterotetramerization Pre-mRNA Cleavage Required For Polyadenylation MRNA Alternative Polyadenylation Messenger Ribonucleoprotein Complex Assembly
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
Drugs
Diseases
GWAS		Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067) Total cholesterol levels ( 33339817)	Height ( 18391951) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Pneumoconiosis in silica exposure ( 24986923) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		77 interacting genes: AGT AHDC1 AMPH ANKRD17 B4GALT2 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RRM2 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	49 interacting genes: APBB1 ARMC7 CSNK2A1 EWSR1 GIN1 ITCH ITSN2 KLHL12 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR155 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR25 MIR29A MIR34A MIR92A1 MIR93 MIRLET7A1 MIRLET7B MIRLET7C MIRLET7D MIRLET7F2 NCK2 NEDD4 NUDT21 OGT OTUB2 PLSCR1 PPIL1 PRPF40A SRSF7 TCERG1 TOLLIP UBAC1 UBQLN4 USP21 WBP4 WWOX WWP1 WWP2 YES1 ZMYND19
Entrez ID		50618	11052
HPRD ID		09193	05401
Ensembl ID		ENSG00000198399	ENSG00000111605
Uniprot IDs		A6H8W8 Q9NZM3	Q16630
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO	3P5T 3P6Y 3Q2S 3Q2T 4B4N 4U0A 4U0B 4WYM 6AY9 6GX9
Enriched GO Terms of Interacting Partners?
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