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HNRNPA1 and PRKDC
Number of citations of the paper that reports this interaction (PubMedID
14704337
)
39
Data Source:
BioGRID
(enzymatic study)
HNRNPA1
PRKDC
Description
heterogeneous nuclear ribonucleoprotein A1
protein kinase, DNA-activated, catalytic subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Cytoplasm
Membrane
Extracellular Exosome
Catalytic Step 2 Spliceosome
Ribonucleoprotein Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Nonhomologous End Joining Complex
Molecular Function
Single-stranded DNA Binding
RNA Binding
Single-stranded RNA Binding
Protein Binding
Protein Domain Specific Binding
MiRNA Binding
Pre-mRNA Binding
Telomeric Repeat-containing RNA Binding
G-rich Strand Telomeric DNA Binding
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Protein Serine Kinase Activity
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
RNA Export From Nucleus
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To Glucose Starvation
MRNA Transport
Nuclear Export
Import Into Nucleus
Cellular Response To Sodium Arsenite
Maturation Of 5.8S RRNA
Telomere Maintenance
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Pro-B Cell Differentiation
T Cell Lineage Commitment
Negative Regulation Of Immunoglobulin Production
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Protein Modification Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Response To Activity
Telomere Capping
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Destabilization
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Spleen Development
Thymus Development
Positive Regulation Of Developmental Growth
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Response To Gamma Radiation
Pathways
FGFR2 alternative splicing
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Caffeine
SF1126
Diseases
GWAS
Meat-related diet (
32066663
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Adult body size (
32376654
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
120 interacting genes:
ABHD16A
APP
BCL2L1
CCDC50
CLK1
DANCR
ERG
ESR1
FEN1
GCH1
H3-4
H3C1
HIPK3
HMGA1
HNRNPH3
KHSRP
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NFKBIA
NR0B2
NR3C1
OGT
PABPN1
PHYHIP
PPIL1
PRKDC
PRMT1
PRMT2
PRMT3
PRRC2A
PSMD9
PTEN
RNF14
RPL21
RPS6KB2
SAFB
SNRNP200
SP1
SREK1
SRPK1
SRPK2
SUFU
TFEC
TNPO1
TRA2B
TRAF6
TSHR
TTF2
XIAP
XRN1
91 interacting genes:
ABL1
AICDA
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
IKBKG
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NR3C1
PARP1
PCNA
PDX1
PGR
POU2F1
PPP6C
PPP6R1
PPP6R3
PRKCD
PTEN
RAD17
RASSF1
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TOP1
TP53
TREX1
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
Entrez ID
3178
5591
HPRD ID
01242
02941
Ensembl ID
ENSG00000135486
ENSG00000253729
Uniprot IDs
A0A024RAZ7
A0A024RB53
P09651
P78527
PDB IDs
1HA1
1L3K
1PGZ
1PO6
1U1K
1U1L
1U1M
1U1N
1U1O
1U1P
1U1Q
1U1R
1UP1
2H4M
2LYV
2UP1
4YOE
5MPG
5MPL
5ZGD
5ZGL
6BXX
6DCL
6J60
7BX7
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
7K0Y
7K10
7K11
7K19
7K1B
7K1J
7K1K
7K1N
Enriched GO Terms of Interacting Partners
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