APAF1 and ACADS

		APAF1	ACADS
Description		apoptotic peptidase activating factor 1	acyl-CoA dehydrogenase short chain
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GO Annotations	Cellular Component	Extracellular Region Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Centrosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding	Acyl-CoA Dehydrogenase Activity Butyryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Response To Hypoxia Kidney Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Brain Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway	Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Butyrate Catabolic Process
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs		ATP	NADH Acetoacetyl-CoA Flavin adenine dinucleotide
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)	Allergic rhinitis ( 30013184) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood metabolite levels ( 24816252) Mean corpuscular volume ( 29403010) Metabolic traits ( 21886157) Metabolite levels ( 31628463 20037589) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Schizophrenia ( 30285260) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Smoking status (ever vs never smokers) ( 30643258) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		30 interacting genes: ACADS APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CCL13 CDK17 CYCS DZIP1 ELK3 FAS FEM1B HIP1 HNF1A HSP90AA1 HSPA1A MRPL19 NLRP1 NR1H4 NUDT4 PAH PPP1CA RPL26L1 TOP1 TRIAP1 UTP20	2 interacting genes: APAF1 IRF7
Entrez ID		317	35
HPRD ID		03755	06053
Ensembl ID		ENSG00000120868	ENSG00000122971
Uniprot IDs		O14727	B4DUH1 E5KSD5 E9PE82 P16219
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE	2VIG
Enriched GO Terms of Interacting Partners?
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